An Oct 2011 report looked at the risk of transferring BPA exposure to infants while breastfeeding. BPA is very common and found in the fat cells of about 90% of the population. It is felt that we get it from various food and beverage products housed in plastics and tin cans. This substance was originally synthesized as an estrogen compound and it is felt that early exposure to this substance can increase the infants risk for hormonal changes and indicates a potential increased risk for breast cancer.
The bottomline of the study was “pregnant and breastfeeding mothers should avoid exposure to BPA as it may affect their daughters’ breast tissue.” That means avoiding use of BPA plastic bottles and most foods and beverages that come in tin cans, (including sodas). Please read the full article below:
BPA Exposure in Utero May Increase Predisposition to Breast Cancer
ScienceDaily (Oct. 3, 2011) — A recent study accepted for publication in Molecular Endocrinology, a journal of The Endocrine Society, found that perinatal exposure to environmentally relevant doses of bisphenol A (BPA) alters long-term hormone response and breast development in mice that may increase the propensity to develop cancer.
BPA, a human-made chemical produced and marketed largely for specific industrial purposes, is detected in body fluids of more than 90 percent of the human population. It was originally synthesized as an estrogenic compound and there has been concern that exposure to BPA could have developmental effects on various hormone-responsive organs including the mammary gland.
“I want it to be clear that we do not provide evidence that BPA exposure causes breast cancer per se,” said Cathrin Brisken, MD, of the Swiss Institute for Experimental Cancer Research and co-author of the study. “We do provide evidence that BPA exposure alters mammary gland development and that this may increase the predisposition of the breast to breast cancer.”
In this study, researchers mimicked human exposure to BPA as it occurs with beverages and food from BPA containing vessels (such as plastics and the lining of tin cans) by adding the compound to the drinking water of breeding mice. Female pups born from BPA-consuming parents were transferred to a BPA-free environment at weaning and followed over time.
Researchers analyzed changes in the mammary gland of female offspring that were exposed to BPA through their mothers in utero and while being breast fed. The mammary glands of BPA exposed females showed an increased response to the hormone progesterone. Lifetime exposure to progesterone has been linked to increase breast cancer risk.
Furthermore, researchers found that adult females who had been exposed to BPA in utero and while breast fed, showed a 1.5 fold increase in cell numbers in their milk ducts. This is comparable to what is seen upon similar exposure to another estrogenic compound, diethyllbestrol (DES). Uterine exposure to DES in the human population has been shown to increase the relative risk of getting breast cancer two-fold as women reach their fifties.
“While we cannot extrapolate these results directly from mice to humans, the possibility that some of the increase in breast cancer incidence observed over the past decades may be attributed to exposure to BPA cannot be dismissed,” said Brisken. “Our study suggests that pregnant and breastfeeding mothers should avoid exposure to BPA as it may affect their daughters’ breast tissue.”
Other researchers working on the study include Ayyakkannu Ayyanan, Ouahiba Laribi, Sonia Schuepbach-Mallepell, Christina Schrick, Maria Gutierrez, Tamara Tanos and Ozden Yalcin-Ozuysal of the Swiss Institute for Experimental Cancer Research; and Gregory Lefebvre and Jacques Rougemont of École polytechnique fédérale de Lausanne in Switzerland.
View the article on Science Daily’s website here.
